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Larriba et al. 2023_Andrology.pdf (3.58 MB)

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Article

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Accepted version

Publication date

2023-05-27

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/200868

Seminal extracellular vesicle sncRNA sequencing reveals altered miRNA/isomiR profiles as sperm retrieval biomarkers for azoospermia

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Related resource

https://doi.org/10.1111/andr.13461

Abstract

Background: Non-invasive molecular biomarkers for classifying azoospermia by origin into either obstructive or non-obstructive/secretory azoospermia, as well as for inferring the spermatogenic reserve of the testis of non-obstructive/secretory azoospermia patients, are of great interest for testicular sperm retrieval outcome prediction for assisted reproduction. Prior analyses of semen small non-coding RNA expression in azoospermia have focused on microRNAs, but there has been a lack of attention on other regulatory small RNA species. In this regard, studying more in-depth expression changes of small non-coding RNA subtypes in small extracellular vesicles from semen of azoospermic individuals could be useful to select additional non-invasive biomarkers with diagnostic/prognostic purposes.

Subject

Esterilitat masculina, Investigació mèdica

Subject (English)

Male sterility, Medicine research

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

LARRIBA, Sara, et al. Seminal extracellular vesicle sncRNA sequencing reveals altered miRNA/isomiR profiles as sperm retrieval biomarkers for azoospermia. Andrology. 2023. ISSN 2047-2927. [consulted: 7 of August of 2026]. Available at: https://hdl.handle.net/2445/200868

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