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2018-07-12

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/139265

Community-acquired bacterial pneumonia in adult HIV-infected patients

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Recurs relacionat

https://doi.org/10.1080/14787210.2018.1495560

Resum

Despite active antiretroviral therapy (ART), community-acquired pneumonia (CAP) remains a major cause of morbidity and mortality among human immunodeficiency virus (HIV)-infected patients and incurs high health costs. Areas covered: This article reviews the most recent publications on bacterial CAP in the HIV-infected population, focusing on epidemiology, prognostic factors, microbial etiology, therapy, and prevention. The data discussed here were mainly obtained from a non-systematic review using Medline, and references from relevant articles. Expert commentary: HIV-infected patients are more susceptible to bacterial CAP. Although ART improves their immune response and has reduced CAP incidence, these patients continue to present increased risk of pneumonia in part because they show altered immunity and because immune activation persists. The risk of CAP in HIV-infected patients and the probability of polymicrobial or atypical infections are inversely associated with the CD4 cell count. Mortality in HIV-infected patients with CAP ranges from 6% to 15% but in well-controlled HIV-infected patients on ART the mortality is low and similar to that seen in HIV-negative individuals. Vaccination and smoking cessation are the two most important preventive strategies for bacterial CAP in well-controlled HIV-infected patients on ART.

Matèries

Pneumònia adquirida a la comunitat, Malalties de l'aparell respiratori, Infeccions per VIH

Matèries (anglès)

Community-acquired pneumonia, Respiratory diseases, HIV infections

Citació

Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

CILLÓNIZ, Catia, et al. Community-acquired bacterial pneumonia in adult HIV-infected patients. Expert Review of Anti-infective Therapy. 2018. Vol. 16, num. 7, pags. 579-588. ISSN 1478-7210. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/139265

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