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2012-05-30

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cc-by (c) Rodriguez Frías, F. et al., 2012
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/43202

Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome

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http://dx.doi.org/10.1371/journal.pone.0037874

Abstract

Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. In this study, the variability of an overlapping polymerase-surface region, critical for NA resistance, is investigated before treatment and under antiviral therapy, with assessment of NA-resistant amino acid changes simultaneously occurring in the same genome (linkage analysis) and their influence on the surface coding region.

Subject

Hepatitis B, Medicaments antivírics, Expressió gènica

Subject (English)

Hepatitis B, Antiviral agents, Gene expression

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citation

RODRÍGUEZ-FRÍAS, Francisco, et al. Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome. PLoS One. 2012. Vol. 7, num. 5, pags. e37874. ISSN 1932-6203. [consulted: 7 of August of 2026]. Available at: https://hdl.handle.net/2445/43202

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