Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome

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dc.contributor.authorRodríguez-Frías, Francisco
dc.contributor.authorTabernero, David
dc.contributor.authorQuer, Josep
dc.contributor.authorEsteban, Juan I.
dc.contributor.authorOrtega, Israel
dc.contributor.authorDomingo, Esteban
dc.contributor.authorCubero, Maria
dc.contributor.authorCamos, Sílvia
dc.contributor.authorFerrer Costa, Carles
dc.contributor.authorSànchez, Àlex (Sànchez Pla)
dc.contributor.authorJardí, Rosendo
dc.contributor.authorSchaper, Melanie
dc.contributor.authorHoms, Maria
dc.contributor.authorGarcía Cehic, Damir
dc.contributor.authorGuardia, Jaume
dc.contributor.authorEsteban, Rafael
dc.contributor.authorButi, Maria
dc.date.accessioned2013-05-07T17:43:09Z
dc.date.available2013-05-07T17:43:09Z
dc.date.issued2012-05-30
dc.date.updated2013-05-07T17:43:09Z
dc.description.abstractSelection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. In this study, the variability of an overlapping polymerase-surface region, critical for NA resistance, is investigated before treatment and under antiviral therapy, with assessment of NA-resistant amino acid changes simultaneously occurring in the same genome (linkage analysis) and their influence on the surface coding region.
dc.format.extent15 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec614276
dc.identifier.issn1932-6203
dc.identifier.pmid22666402
dc.identifier.urihttps://hdl.handle.net/2445/43202
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0037874
dc.relation.ispartofPLoS One, 2012, vol. 7, num. 5, p. e37874
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0037874
dc.rightscc-by (c) Rodriguez Frías, F. et al., 2012
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Genètica, Microbiologia i Estadística)
dc.subject.classificationHepatitis B
dc.subject.classificationMedicaments antivírics
dc.subject.classificationExpressió gènica
dc.subject.otherHepatitis B
dc.subject.otherAntiviral agents
dc.subject.otherGene expression
dc.titleUltra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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