Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/184725
Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
With innumerable clinical failures of target-specific drug candidates for multifactorial diseases, such as Alzheimer's disease (AD), which remains inefficiently treated, the advent of multitarget drug discovery has brought a new breath of hope. Here, we disclose a class of 6-chlorotacrine (huprine)‒TPPU hybrids as dual inhibitors of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE), a multitarget profile to provide cumulative effects against neuroinflammation and memory impairment. Computational studies confirmed the gorge-wide occupancy of both enzymes, from the main site to a secondary site, including a so far non-described AChE cryptic pocket. The lead compound displayed in vitro dual nanomolar potencies, adequate brain permeability, aqueous solubility, and human microsomal stability and lack of neurotoxicity, and rescued memory, synaptic plasticity and neuroinflammation in an AD mouse model, after low dose chronic oral administration.
Matèries (anglès)
Citació
Citació
CODONY GISBERT, Sandra, PONT MASANET, Caterina, GRIÑÁN FERRÉ, Christian, DI PEDE MATTATELLI, Ania, CALVÓ-TUSELL, Carla, FEIXAS, Ferran, OSUNA, Sílvia, JARNE FERRER, Júlia, NALDI, Marina, BARTOLINI, Manuela, LOZA, María isabel, BREA, José, Bartolini, PÉREZ, Belén, BARTRA, Clara, SANFELIU I PUJOL, Coral, JUÁREZ JIMÉNEZ, Jordi, MORISSEAU, Christophe, HAMMOCK, Bruce d., PALLÀS I LLIBERÍA, Mercè, VÁZQUEZ CRUZ, Santiago, MUÑOZ-TORRERO LÓPEZ-IBARRA, Diego. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. _Journal of Medicinal Chemistry_. 2022. Vol. 65, núm. 6, pàgs. 4909-4925. [consulta: 28 de gener de 2026]. ISSN: 0022-2623. [Disponible a: https://hdl.handle.net/2445/184725]