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2013-03-27

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126080

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

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https://doi.org/10.1038/ng.2566

Resum

TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10−7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10−8) and BRCA1 mutation carrier (P = 1.1 × 10−5) breast cancers and altered promoter assay signal. The minor allele at the peak 2 SNP rs7705526 associates with longer telomeres (P = 2.3 × 10−14), higher risk of low-malignant-potential ovarian cancer (P = 1.3 × 10−15) and greater promoter activity. The minor alleles at the peak 3 SNPs rs10069690 and rs2242652 increase ER-negative (P = 1.2 × 10−12) and BRCA1 mutation carrier (P = 1.6 × 10−14) breast and invasive ovarian (P = 1.3 × 10−11) cancer risks but not via altered telomere length. The cancer risk alleles of rs2242652 and rs10069690, respectively, increase silencing and generate a truncated TERT splice variant.

Matèries

Càncer d'ovari, Càncer de mama, Telòmer

Matèries (anglès)

Ovarian cancer, Breast cancer, Telomere

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BLANCO GUILLERMO, Ignacio, Australian Cancer Study, Australian Ovarian Cancer Study Group, GENICA (Gene Environment Interaction and Breast Cancer), SWE-BRCA Group, HEBON Investigators, EMBRACE Collaborators, GEMO Study Collaborators. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. _Nature Genetics_. 2013. Vol. 45, núm. 4, pàgs. 371-384. [consulta: 23 de gener de 2026]. ISSN: 1061-4036. [Disponible a: https://hdl.handle.net/2445/126080]

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