Miniatura

Fitxers

196415.pdf (766.78 KB)

Tipus de document

Article

Versió

Versió acceptada

Data de publicació

2017-01-15

Llicència de publicació

cc-by-nc-nd (c) Elsevier B.V., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/226385

High cognitive reserve in bipolar disorders as a moderator of neurocognitive impairment

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.jad.2016.10.012

Resum

Background: Cognitive reserve (CR) reflects the capacity of the brain to endure neuropathology, minimize clinical manifestations and successfully complete cognitive tasks. The present study aims to determine whether high CR may constitute a moderator of cognitive functioning in bipolar disorder (BD). Methods: 102 patients with BD and 32 healthy controls were enrolled. All patients met DSM-IV criteria for I or II BD and were euthymic (YMRS≤6 and HDRS≤8) during a 6-month period. All participants were tested with a comprehensive neuropsychological battery, and a Cerebral Reserve Score (CRS) was estimated. Subjects with a CRS below the group median were classified as having low CR, whereas participants with a CRS above the median value were considered to have high CR. Results: Participants with BD with high CR displayed a better performance in measures of attention (digits forward: F=4.554, p=0.039); phonemic and semantic verbal fluency (FAS: F=9.328, p=0.004; and Animal Naming: F=8.532, p=0.006); and verbal memory (short cued recall of California Verbal Learning Test: F=4.236, p=0.046), after multivariable adjustment for potential confounders, including number of admissions and prior psychotic symptoms. Limitations: The cross-sectional design of the study does not allow the establishment of causal inferences. Additionally, the small size of the sample may have limited some results. Conclusions: High cognitive reserve may therefore be a valuable construct to explore for predicting neurocognitive performance in patients with BD regarding premorbid status.

Matèries

Trastorn bipolar, Cognició, Neurologia

Matèries (anglès)

Manic-depressive illness, Cognition, Neurology

Citació

Col·leccions

Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))

Citació

GRANDE I FULLANA, Iria, SÁNCHEZ-MORENO, José, SOLÉ CABEZUELO, Brisa, JIMÉNEZ MARTÍNEZ, Ester, TORRENT FONT, Carla, BONNÍN ROIG, Caterina del mar, VARO, Cristina, TABARÉS-SEISDEDOS, Rafael, BALANZÁ-MARTÍNEZ, Vicent, VALLS, Elia, MORILLA, Ivette, CARVALHO, André f., AYUSO-MATEOS, J.l., VIETA I PASCUAL, Eduard, MARTÍNEZ-ARÁN, Anabel. High cognitive reserve in bipolar disorders as a moderator of neurocognitive impairment. _Journal of Affective Disorders_. 2017. Vol. 208, núm. 621-627. [consulta: 6 de febrer de 2026]. ISSN: 0165-0327. [Disponible a: https://hdl.handle.net/2445/226385]

Exportar metadades

JSON - METS

Compartir registre