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bustamante2015_1913.pdf (1.05 MB)

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Article

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Accepted version

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2015-04-28

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cc by-nc (c) Instituto Oswaldo Cruz, 2015
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/99571

Reaching for the Holy Grail: insights from infection/cure models on the prospects for vaccines for Trypanosoma cruzi infection

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http://dx.doi.org/10.1590/0074-02760140440

Abstract

Prevention of Trypanosoma cruzi infection in mammals likely depends on either prevention of the invading trypomastigotes from infecting host cells or the rapid recognition and killing of the newly infected cells by T. cruzi-specific T cells. We show here that multiple rounds of infection and cure (by drug therapy) fails to protect mice from reinfection, despite the generation of potent T cell responses. This disappointing result is similar to that obtained with many other vaccine protocols used in attempts to protect animals from T. cruzi infection. We have previously shown that immune recognition of T. cruzi infection is significantly delayed both at the systemic level and at the level of the infected host cell. The systemic delay appears to be the result of a stealth infection process that fails to trigger substantial innate recognition mechanisms while the delay at the cellular level is related to the immunodominance of highly variable gene family proteins, in particular those of the trans-sialidase family. Here we discuss how these previous studies and the new findings herein impact our thoughts on the potential of prophylactic vaccination to serve a productive role in the prevention of T. cruzi infection and Chagas disease.

Subject

Malaltia de Chagas, Vacunes

Subject (English)

Chagas' disease, Vaccines

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Articles publicats en revistes (ISGlobal)

Citation

BUSTAMANTE, Juan Manuel and TARLETON, Rick. Reaching for the Holy Grail: insights from infection/cure models
                on the prospects for vaccines for Trypanosoma cruzi infection. Memorias do Instituto Oswaldo Cruz. 2015. Vol. 110, num. 3, pags. 445-451. ISSN 0074-0276. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/99571

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