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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/149433
Datasets for the validation of the 'in vivo' siRNA-silencing of CD40 and for the detection of new markers of aterosclerosis progression in ApoE-deficient mice
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Data presented in this Data in Brief article correspond to the article 'in vivo' silencing of CD40 reduces progression of experimental atherogenesis through a NFκB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis' (M. Hueso, L. De Ramon, E. Navarro, E. Ripoll, J.M. Cruzado, J.M. Grinyo, J. Torras, 2016) [1]. Here, we describe the validation of the silencing of CD40 expression with a specific siRNA in ApoE−/− mouse aortas, and its systemic effects on splenic lymphocytic subpopulations as well as on the infiltration of aortic intima by F4/80+, galectin-3+ macrophages or by NF-κB+ cells. We also show the output of a Gene Ontology and TLDA analysis which allowed the detection of potential mediators of atherosclerosis progression. We provide the scientific community with a set of genes whose expression is increased during atherosclerosis progression but downregulated upon CD40 silencing.
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HUESO VAL, Miguel, RAMON, Laura de, NAVARRO, Estanis, RIPOLL LLAGOSTERA, Èlia, CRUZADO, Josep ma., GRINYÓ BOIRA, Josep m., TORRAS AMBRÒS, Joan. Datasets for the validation of the 'in vivo' siRNA-silencing of CD40 and for the detection of new markers of aterosclerosis progression in ApoE-deficient mice. _Data in Brief_. 2016. Vol. 9, núm. 1105-1112. [consulta: 21 de gener de 2026]. ISSN: 2352-3409. [Disponible a: https://hdl.handle.net/2445/149433]