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2025-04-01

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cc-by-nc-nd (c) Kavya Anguluri, et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/227501

Supramolecular gels for antimicrobial photodynamic therapy against E. coli and S. aureus

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Recurs relacionat

https://doi.org/10.1016/j.pdpdt.2025.104529

Resum

Singlet oxygen (SO) reacts with organic molecules, for example in degrading environmental contaminants and causing toxicity to cells in photodynamic therapy (PDT). The relevance of SO in the environmental and biomedical domains has fuelled research towards improved methodologies for its efficient generation. In this paper, we report the use of a bis-imidazolium-based amphiphile that forms supramolecular gels in water-ethanol mixtures encapsulating SO generating chromophores. The gels comprise twisted fibres that incorporate one of four different porphyrins: 5,10,15,20-tetrakis(N-methyl-4-pyridinium)porphyrin tetraiodide (TPPP), 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP), 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin (TPP-3OH) and 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin (TPP-4OH). Rheological measurements confirmed viscoelastic properties characteristic of these types of supramolecular gels, suggesting their potential as effective local PDT delivery systems. Enhanced SO generation within the hydrogel matrix compared to the solution of the chromophores was observed in suspension in a spectrophotometer using uric acid as the molecular probe. The SO generation was also shown through antimicrobial PDT (aPDT) studies. The TPPP-containing gel showed the highest reduction in the colony forming unit (CFU) count, which is 94% against E. coli and 100% against S. aureus. These results indicate that the porphyrin gels based on a gemini amphiphile with a high level of SO production are of significant interest and have a lot of potential use in aPDT.

Matèries

Química supramolecular, Fotofarmacologia, Fototeràpia

Matèries (anglès)

Supramolecular chemistry, Photopharmacology, Phototherapy

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Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

Citació

ANGULURI, Kavya, et al. Supramolecular gels for antimicrobial photodynamic therapy against E. coli and S. aureus. Photodiagnosis and Photodynamic Therapy. 2025. Vol. 52. ISSN 1572-1000. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/227501

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