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Purging behavior modulates the relationships of hormonal and behavioral parameters in women with eating disorders
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Background/aims: There is ample consensus that there is a neurophysiological basis for the eating disorders (ED). Traits of personality translate into behavioural traits, purging being a well defined transversal example. Direct implication of steroid hormones on ED has been seldom studied, despite their effects on behaviour. Methods: After psychological interview analysis 57 ED female patients (31 purgative and 26 non-purgative), and 17 female controls were studied. Metabolic parameters and analysis of androgen, estrogen and glucocorticoid hormones were determined in parallel to the psychopathological profile (EDI-2 and SCL-90-R) and anthropometric measurements. Results: Psychometric tests showed clear differences between ED and controls, but there were few hormonal-metabolic significant differences. In purgative ED there were repeated (significant) positive correlations with CBG, and negative with SHBG, versus eating and general psychopathology. In non-purging, there were positive correlations for deoxycortisol, free fatty acids, albumin and negative for aspartate aminotransferase and psychopathological traits. Conclusion: The data hint at CBG/corticosteroids and sexual hormones/SHBG to be involved in purging behaviour and its psychopathology and severity scores. Correlations of selected psychometric data and the CBG/SHBG levels in purging may eventually result in clinical markers. This approach may provide additional clues for understanding the pathogenesis of the ED.
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GRASA MARTÍNEZ, Maria del mar, VILLARREAL, Laura, GRANERO, Roser, VILÀ BAÑOS, Ruth, PENELO WERNER, Eva, AGÜERA, Zaida, JIMÉNEZ-MURCIA, Susana, ROMERO ROMERO, María del mar, MENCHÓN MAGRIÑÁ, José manuel, REMESAR BETLLOCH, Xavier, FERNÁNDEZ ARANDA, Fernando, ALEMANY, Marià. Purging behavior modulates the relationships of hormonal and behavioral parameters in women with eating disorders. _Neuropsychobiology_. 2013. Vol. 67, núm. 4, pàgs. 230-240. [consulta: 20 de gener de 2026]. ISSN: 0302-282X. [Disponible a: https://hdl.handle.net/2445/130534]