Pre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics

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dc.contributor.authorFarzam, Parisa
dc.contributor.authorJohansson, Johannes D.
dc.contributor.authorMireles, Miguel
dc.contributor.authorJiménez Valerio, Gabriela
dc.contributor.authorMartínez Lozano, Mar
dc.contributor.authorChoe, Regine
dc.contributor.authorCasanovas i Casanovas, Oriol
dc.contributor.authorDurduran, Turgut
dc.date.accessioned2018-09-10T09:54:31Z
dc.date.available2018-09-10T09:54:31Z
dc.date.issued2017-05-01
dc.date.updated2018-07-24T12:07:45Z
dc.description.abstractThe longitudinal effect of an anti-vascular endothelial growth factor receptor 2 (VEGFR-2) antibody (DC 101) therapy on a xenografted renal cell carcinoma (RCC) mouse model was monitored using hybrid diffuse optics. Two groups of immunosuppressed male nude mice (seven treated, seven controls) were measured. Tumor microvascular blood flow, total hemoglobin concentration and blood oxygenation were investigated as potential biomarkers for the monitoring of the effect of therapy twice a week and were related to the final treatment outcome. These hemodynamic biomarkers have shown a clear differentiation between two groups by day four. Moreover, we have observed that pre-treatment values and early changes in hemodynamics are highly correlated with the therapeutic outcome demonstrating the potential of diffuse optics to predict the therapy response at an early time point. (C) 2017 Optical Society of America
dc.format.extent20 p.
dc.format.mimetypeapplication/pdf
dc.identifier.pmid28663891
dc.identifier.urihttps://hdl.handle.net/2445/124399
dc.language.isoeng
dc.publisherOptical Society of America
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1364/BOE.8.002563
dc.relation.ispartofBiomedical Optics Express, 2017, vol. 8, num. 5, p. 2563-2582
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/281830/EU//STROMALIGN
dc.relation.urihttps://doi.org/10.1364/BOE.8.002563
dc.rights(c) Optical Society of America, 2017
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationCàncer de ronyó
dc.subject.classificationTomografia òptica
dc.subject.otherRenal cancer
dc.subject.otherOptical tomography
dc.titlePre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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