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PIIS104327602300108X.pdf (1.81 MB)

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Article

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Published version

Publication date

2023-06-17

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cc by-nc-nd (c) Moraitis, Ilias et al., 2023
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/202603

Gut microbiota controlling radiation-induced enteritis and intestinal regeneration

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https://doi.org/10.1016/j.tem.2023.05.006

Abstract

Cancer remains the second leading cause of mortality, with nearly 10 million deaths worldwide in 2020. In many cases, radiotherapy is used for its anticancer effects. However, radiation causes healthy tissue toxicity as a side effect. In intra-abdominal and pelvic malignancies, the healthy bowel is inevitably included in the radiation field, causing radiation-induced enteritis and dramatically affecting the gut microbiome. This condition is associated with significant morbidity and mortality that impairs cancer patients' and survivors' quality of life. This Review provides a critical overview of the main drivers in modulating the gut microenvironment in homeostasis, disease, and injury, focusing on gut microbial metabolites and microorganisms that influence epithelial regeneration upon radiation injury.

Subject

Medicina regenerativa, Microbiota intestinal

Subject (English)

Regenerative medicine, Gastrointestinal microbiome

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

MORAITIS, Ilias, GUIU, Jordi and RUBERT, Josep. Gut microbiota controlling radiation-induced enteritis and intestinal regeneration. Trends in Endocrinology & Metabolism. 2023. Vol. 34, num. 8, pags. 489-501. ISSN 1879-3061. [consulted: 9 of June of 2026]. Available at: https://hdl.handle.net/2445/202603

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