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fendo-13-868795.pdf (2.63 MB)

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2022-06-29

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cc by (c) Martínez Urbistondo, Diego et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/188891

Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort

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https://doi.org/10.3389/fendo.2022.868795

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ObjectiveTo evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic syndrome (MetS). MethodsBaseline and 1 year follow up data from the PREDIMED-plus cohort (men and women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as affected by lifestyle during 1 year of follow up. ResultsData from 5205 patients with mean age of 65 years and a 48% of female participants. Adjusted linear multivariate mixed regression models showed that patients with lower probability of NAFLD (HSI < 36 points) were more responsive to er-MeDiet (beta 0.64 vs beta 0.05 per er-MeDiet adherence point, p< 0.01) and PA (beta 0.05 vs beta 0.01 per MET-h/week, p = 0.001) than those with high probability for NAFLD in terms Physical SF-36 summary in the 1 year follow up. 10 points of er-MeDiet adherence and 50 MET-h/week were thresholds for a beneficial effect of lifestyle on HRQoL physical domain in patients with lower probability of NAFLD. ConclusionThe evaluation of NAFLD by the HSI index in patients with MetS might identify subjects with different prospective sensitivity to lifestyle changes in terms of physical HRQoL.

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Síndrome metabòlica, Malalties del fetge, Exercici, Estils de vida

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Metabolic syndrome, Liver diseases, Exercise, Lifestyles

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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MARTÍNEZ URBISTONDO, Diego, SAN CRISTÓBAL, Rodrigo, VILLARES, Paula, MARTÍNEZ-GONZÁLEZ, Miguel ángel, BABIO, Nancy, CORELLA PIQUER, Dolores, DEL VAL, José luis, ORDOVÁS, José maría, ALONSO GÓMEZ, Ángel m., WÄRNBERG, Julia, VIOQUE, Jesús, ROMAGUERA, Dora, LÓPEZ MIRANDA, José, ESTRUCH RIBA, Ramon, TINAHONES, Francisco j., LAPETRA, José, SERRA MAJEM, Lluís, BUENO CAVANILLAS, Aurora, TUR, Josep a., MARCOS, Alba, PINTÓ SALA, Xavier, DELGADO RODRÍGUEZ, Miguel, MATÍA MARTÍN, Pilar, VIDAL I CORTADA, Josep, VÁZQUEZ, Clotilde, ROS RAHOLA, Emilio, BULLÓN VELA, María vanessa, PALAU, Antoni, MASAGUÉ, Marta, ABETE, Itziar, MORENO RODRÍGUEZ, Anai, CANDELA GARCÍA, Inma, KONIECZNA, Jadwiga, GARCÍA RÍOS, Antonio, LECEA JUÁREZ, Oscar, MARTÍN, Paco, GODAY ARNÓ, Albert, ZULET, M. angeles, VAQUERO LUNA, Jessica, SAYÓN OREA, Carmen, MEGÍAS, Isabel, BALTASAR, Enric, MARTÍNEZ, J. alfredo, DAIMIEL, Lidia. Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort. _Frontiers in Endocrinology_. 2022. Vol. 13, núm. 868795. [consulta: 29 de gener de 2026]. ISSN: 1664-2392. [Disponible a: https://hdl.handle.net/2445/188891]

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