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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/126344
Prefrontal gray matter and motivation for treatment in cocaine-dependent individuals with and without personality disorders
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Addiction treatment is a long-term goal and therefore prefrontal–striatal regions regulating
goal-directed behavior are to be associated with individual differences on treatment motivation.
We aimed at examining the association between gray matter volumes in prefrontal
cortices and striatum and readiness to change at treatment onset in cocaine users with
and without personality disorders. Participants included 17 cocaine users without psychiatric
comorbidities, 17 cocaine users with Cluster B disorders, and 12 cocaine users with
Cluster C disorders. They completed the University of Rhode Island Change Assessment
Scale, which measures four stages of treatment change (precontemplation, contemplation,
action, and maintenance) and overall readiness to change, and were scanned in a 3T MRI
scanner. We defined three regions of interest (ROIs): the ventromedial prefrontal cortex
(including medial orbitofrontal cortex and subgenual and rostral anterior cingulate cortex),
the dorsomedial prefrontal cortex (i.e., superior medial frontal cortex), and the neostriatum
(caudate and putamen). We found that readiness to change correlated with different
aspects of ventromedial prefrontal gray matter as a function of diagnosis. In cocaine users
with Cluster C comorbidities, readiness to change positively correlated with gyrus rectus
gray matter, whereas in cocaine users without comorbidities it negatively correlated
with rostral anterior cingulate cortex gray matter. Moreover, maintenance scores positively
correlated with dorsomedial prefrontal gray matter in cocaine users with Cluster C comorbidities,
but negatively correlated with this region in cocaine users with Cluster B and
cocaine users without comorbidities. Maintenance scores also negatively correlated with
dorsal striatum gray matter in cocaine users with Cluster C comorbidities. We conclude
that the link between prefrontal–striatal gray matter and treatment motivation is modulated
by co-existence of personality disorders.
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MORENO LÓPEZ, Laura, et al. Prefrontal gray matter and motivation for treatment in cocaine-dependent individuals with and without personality disorders. Frontiers in Psychiatry. 2014. Vol. 5. [consulted: 9 of October of 2026]. Available at: https://hdl.handle.net/2445/126344