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Bicelles: new nano systems for skin applications
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Bicellar systems are lipid nanostructures formed by long- and short-chained phospholipids dispersed in aqueous
solution. Because of their attractive combination of lipid composition, small size and morphological versatility, bicelles
became new targets for skin research. Bicelles modify the skin biophysical parameters and modulate the skin barrier function acting as enhancers for drug penetration. Moreover, these aggregates have the ability to penetrate through the narrow
intercellular spaces of the skin stratum corneum and to reinforce its lipid lamellae. Their structures allows for the incorporation of different molecules that can be carried through the skin layers. The
remarkable versatility of bicelles is their most important characteristic, which makes it possible their use in different fields.
These aggregates represent new nanosystems for skin applications. In this work we provide an overview of the main properties of
bicelles and their effects on the skin.
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BARBOSA BARROS, Lucyanna, RODRIGUEZ, Gelen, CÓCERA NÚÑEZ, Mercedes, RUBIO TOLEDANO, Laia, ESTELRICH I LATRÀS, Joan, MAZA RIBERA, Alfonso de la, LÓPEZ SERRANO, Olga. Bicelles: new nano systems for skin applications. _Recent Advances in Pharmaceutical Sciences II_. 2012. Vol. Editor: Diego Muñoz-Torrero, núm. Diego Haro and Joan Vallès, pàgs. Chapter 8. [consulta: 28 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/32195]