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New π-arene ruthenium (II) piano-stool complexes with nitrogen ligands
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The synthesis, characterization, DNA interaction and antiproliferative behavior of new π-arene ruthenium(II) piano-stool complexes with nitrogen ligands are described. Three series of organometallic compounds of formulae [RuCl2(η6-p-cym)L] were synthesized (with L = 2-, 3- or 4-methylpyridine; L = 2,3-, 2,4-, 2,5-, 3,4-, 3,5-dimethylpyridine and L = 1,2-, 1,3- 1,4-methylaminobenzene). The crystal structures of [RuCl2(p-cym)(4-methylpyridine)], [RuCl2(p-cym)(3,4-dimethylpyridine)] and [RuCl2(p-cym)(1,4-methylaminobenzene)] were resolved and the characterization was completed by spectroscopic UV-vis, FT-IR and 1H NMR studies. Electrochemical experiments were performed by cyclic voltammetry to estimate the redox potential of the Ru(II)/Ru(III) couple. The interaction with plasmid pBR322 DNA was studied through the examination of the electrophoretical mobility and atomic force microscopy, and interaction with ct-DNA by circular dichroism, viscosity measurements and fluorescence studies based on the DNA-ethidium bromide complex. The antiproliferative behavior of the series with L = methylpyridine was assayed against two tumor cell lines, i.e. LoVo and MiaPaca. The results revealed a moderate cytotoxicity with a higher activity for the LoVo cell line compared to the MiaPaca one.
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GRAU, Jordi (grau bigordà), NOÉ MATA, Verónica, CIUDAD I GÓMEZ, Carlos julián, PRIETO VILLANUEVA, Ma. josé, FONT BARDIA, Ma. mercedes, CALVET PALLÀS, Maria teresa, MORENO AGUADO, Víctor. New π-arene ruthenium (II) piano-stool complexes with nitrogen ligands. _Journal of Inorganic Biochemistry_. 2012. Vol. 109, núm. 72-81. [consulta: 23 de gener de 2026]. ISSN: 0162-0134. [Disponible a: https://hdl.handle.net/2445/209842]