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2018-07-18

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cc-by (c) Cillóniz, Catia et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/130723

Twenty-year trend in mortality among hospitalized patients with pneumococcal community-acquired pneumonia

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https://doi.org/10.1371/journal.pone.0200504

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Background There is only limited information on mortality over extended periods in hospitalized patients with pneumococcal community-acquired pneumonia (CAP). We aimed to evaluate the 30-day mortality and whether is changed over a 20-year period among immunocompetent adults hospitalized with pneumococcal CAP. Methods We conducted a retrospective observational study of data that were prospectively collected at the Hospital Clinic of Barcelona of all adult patients hospitalized with diagnosis of pneumococcal CAP over a 20-year period. To aid analysis, results were divided into four periods of 5 years each (1997-2001, 2002-2006, 2007-2011, 2012-2016). The primary outcome was 30-day mortality, but secondary outcomes included intensive care unit (ICU) admission, lengths of hospital and ICU-stays, ICU-mortality, and need of mechanical ventilation. Results From a cohort of 6,403 patients with CAP, we analyzed the data for 1,120 (17%) adults with a diagnosis of pneumococcal CAP. Over time, we observed decreases in the rates of alcohol consumption, smoking, influenza vaccination, and older patients (age ≥65 years), but increases in admissions to ICU and the need for non-invasive mechanical ventilation. The overall 30-day mortality rate was 8% (95% confidence interval, 6%-9%; 84 of 1,120 patients) and did not change significantly between periods (p = 0.33). Although, we observed a decrease in ICU-mortality comparing the first period (26%) to the second one (10%), statistical differences disappeared with adjustment (p0.38). Conclusion Over time, 30-day mortality of hospitalized pneumococcal CAP did not change significantly. Nor did it change in the propensity-adjusted multivariable analysis. Since mortality in pneumococcal pneumonia has remained unaltered for many years despite the availability of antimicrobial agents with proven in vitro activity, other non-antibiotic strategies should be investigated.

Matèries

Pneumònia adquirida a la comunitat, Septicèmia, Mortalitat, Malalts hospitalitzats

Matèries (anglès)

Community-acquired pneumonia, Septicemia, Mortality, Hospital patients

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (ISGlobal)

Citació

CILLÓNIZ, Catia, LIAPIKOU, Adamantia, MARTÍN LOECHES, Manuel, GARCIA VIDAL, Carolina, GABARRÚS, Albert, CECCATO, Adrian, MAGDALENO, Daniel, MENSA PUEYO, Josep, MARCO REVERTÉ, Francesc, TORRES MARTÍ, Antoni. Twenty-year trend in mortality among hospitalized patients with pneumococcal community-acquired pneumonia. _PLoS One_. 2018. Vol. 13, núm. 7, pàgs. e0200504. [consulta: 7 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/130723]

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