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2015-05-26

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cc by (c) Teo et al., 2015
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/69241

Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission

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http://dx.doi.org/10.1186/s12936-015-0736-x

Abstract

BACKGROUND: Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. METHODS: Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin. RESULTS: Malaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p < 0.0001). In contrast, median levels of opsonizing antibodies did not change, although levels for some individuals changed significantly. In multivariate analysis, the malaria prevention regimen did not influence antibody levels. CONCLUSION: Different preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea. TRIAL REGISTRATIONS: NCT01136850.

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Malària, Plasmodium falciparum, Immunitat, Embaràs

Subject (English)

Malaria, Plasmodium falciparum, Immunity, Pregnancy

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TEO, Andrew, et al. Malaria preventive therapy in pregnancy and its potential impact
                on immunity to malaria in an area of declining transmission. Malaria Journal. 2015. Vol. 14, num. 215. ISSN 1475-2875. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/69241

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