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2022_Pharmaceutics_Liposomal_FernandezX.pdf (2.59 MB)

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Data de publicació

2022-04-24

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cc by (c) Luca, Maria De et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/185447

Liposomal Formulations to Improve Antioxidant Power of Myrtle Berry Extract for Potential Skin Application

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Recurs relacionat

https://doi.org/10.3390/pharmaceutics14050910

Resum

Many substances in plant extracts are known for their biological activities. These substances act in different ways, exerting overall protective effects against many diseases, especially skin disorders. However, plant extracts’ health benefits are often limited by low bioavailability. To overcome these limitations, drug delivery systems can be employed. In this study, we evaluated the antioxidant power of an ethanolic extract from Myrtus communis L. (myrtle) berries through colorimetric tests (DPPH and FRAP). The antioxidant activity was also verified by using fibroblast cell culture through cellular Reactive Oxygen Species (ROS) levels measurements. Moreover, the myrtle extract was formulated in phospholipid vesicles to improve its bioavailability and applicability. Myrtle liposomes were characterized by size, surface charge, storage stability, and entrapment efficiency; visualized by using cryo-TEM images; and assayed for cytocompatibility and anti-ROS activity. Our results suggest that myrtle liposomes were cytocompatible and improved the extract’s antioxidant power in fibroblasts, suggesting a potential skin application for these formulations and confirming that nanotechnologies could be a valid tool to enhance plant extracts’ potentialities.

Matèries

Liposomes, Antioxidants, Malalties de la pell, Compostos bioactius vegetals

Matèries (anglès)

Liposomes, Antioxidants, Skin diseases, Plant bioactive compounds

Citació

Col·leccions

Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (ISGlobal)

Citació

LUCA, Maria De, et al. Liposomal Formulations to Improve Antioxidant Power of Myrtle Berry Extract for Potential Skin Application. Pharmaceutics. 2022. Vol. 14, num. 5, pags. 910. ISSN 1999-4923. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/185447

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