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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/174233
Ancestral function ofInhibitors-of-kappaB regulates Caenorhabditis elegans development
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Mammalian I kappa B proteins (I kappa Bs) exert their main function as negative regulators of NF-kappa B, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for I kappa Bs has been shown to affect stemness and cell differentiation. However, the involvement of NF-kappa B in this function has not been excluded. NFKI-1 and IKB-1 are I kappa B homologs in Caenorhabditis elegans, which lacks NF-kappa B nuclear effectors. We found that nfki-1 and ikb-1 mutants display developmental defects that phenocopy mutations in Polycomb and UTX-1 histone demethylase, suggesting a role for C. elegans I kappa Bs in chromatin regulation. Further supporting this possibility (1) we detected NFKI-1 in the nucleus of cells; (2) NFKI-1 and IKB-1 bind to histones and Polycomb proteins, (3) and associate with chromatin in vivo, and (4) mutations in nfki-1 and ikb-1 alter chromatin marks. Based on these results, we propose that ancestral I kappa B inhibitors modulate Polycomb activity at specific gene subsets with an impact on development.
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BRENA, David, BERTRAN, Joan, PORTA DE LA RIVA, Montserrat, GUILLEN, Yolanda, CORNES, Eric, KUKHTAR, Dmytro, CAMPOS VICENS, Lluís, FERNÁNDEZ, Lierni, PECHARROMAN, Irene, GARCÍA LÓPEZ, Albert, ISLAM, Abul b. m. m. k., MARRUECOS, Laura, BIGAS SALVANS, Anna, CERÓN MADRIGAL, Julián, ESPINOSA, Lluís. Ancestral function ofInhibitors-of-kappaB regulates Caenorhabditis elegans development. _Scientific Reports_. 2020. Vol. 10. [consulta: 25 de febrer de 2026]. [Disponible a: https://hdl.handle.net/2445/174233]