Electric field causes volumetric changes in the human brain

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dc.contributor.authorArgyelan, Miklos
dc.contributor.authorOltedal, Leif
dc.contributor.authorDeng, Zhi-De
dc.contributor.authorWade, Benjamin S. C.
dc.contributor.authorBikson, Marom
dc.contributor.authorJoanlanne, Andrea
dc.contributor.authorSanghani, Sohag
dc.contributor.authorBartsch, Hauke
dc.contributor.authorCano Català, Marta
dc.contributor.authorDale, Anders M.
dc.contributor.authorDannlowski, Udo
dc.contributor.authorDols, Annemiek
dc.contributor.authorEnneking, Verena
dc.contributor.authorEspinoza, Randall
dc.contributor.authorKessler, Ute
dc.contributor.authorNarr, Katherine
dc.contributor.authorOedegaard, Ketil J.
dc.contributor.authorOudega, Mardien L.
dc.contributor.authorRedlich, Ronny
dc.contributor.authorStek, Max L.
dc.contributor.authorTakamiya, Akihiro
dc.contributor.authorEmsell, Louise
dc.contributor.authorBouckaert, Filip
dc.contributor.authorSienaert, Pascal
dc.contributor.authorPujol, Jesús
dc.contributor.authorTendolkar, Indira
dc.contributor.authorEijndhoven, Philip van
dc.contributor.authorPetrides, Georgios
dc.contributor.authorMalhotra, Anil K.
dc.contributor.authorAbbott, Christopher
dc.date.accessioned2020-07-02T07:37:32Z
dc.date.available2020-07-02T07:37:32Z
dc.date.issued2019-10-23
dc.date.updated2020-07-01T11:14:10Z
dc.description.abstractRecent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.
dc.format.extent20 p.
dc.format.mimetypeapplication/pdf
dc.identifier.pmid31644424
dc.identifier.urihttps://hdl.handle.net/2445/167278
dc.language.isoeng
dc.publishereLife Sciences Publications
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.7554/eLife.49115
dc.relation.ispartofElife, 2019, Vol. 8, p. e49115
dc.relation.urihttps://doi.org/10.7554/eLife.49115
dc.rightsCC0 Argyelan et al., 2019
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationTeràpia de xoc
dc.subject.classificationCamps elèctrics
dc.subject.classificationCervell
dc.subject.otherShock therapy
dc.subject.otherElectric fields
dc.subject.otherBrain
dc.titleElectric field causes volumetric changes in the human brain
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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