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2018-02-01

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cc-by (c) Ibáñez Sanz, Gemma et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/121875

Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study

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Recurs relacionat

https://doi.org/10.1038/s41598-018-20349-6

Resum

A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. We aim to evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk of colorectal cancer (CRC) in the MCC-Spain study, a case-control study performed in Spain that included 2140 cases of CRC and 3950 population controls. Subjects were interviewed on sociodemographic factors, lifestyle, family and medical history and regular drug use. Adjusted odds ratios and their 95% confidence intervals were estimated. The reported frequency of chondroitin and/or glucosamine use was 2.03% in controls and 0.89% in cases. Users had a reduced risk of CRC (OR: 0.47; 95% CI: 0.28-0.79), but it was no longer significant when adjusted for NSAID (nonsteroidal anti-inflammatory drugs) use (OR: 0.82; 95% CI: 0.47-1.40). A meta-analysis with previous studies suggested a protective effect, overall and stratified by NSAID use (OR: 0.77; 95% CI: 0.62-0.97). We have not found strong evidence of an independent preventive effect of CG on CRC in our population because the observed effects of our study could be attributed to NSAIDs concurrent use. These results merit further research due to the safety profile of these drugs.

Matèries

Espanya, Càncer colorectal, Estudi de casos, Medicina preventiva

Matèries (anglès)

Spain, Colorectal cancer, Case studies, Preventive medicine

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)

Citació

IBÁÑEZ SANZ, Gemma, DÍEZ VILLANUEVA, Anna, VILORIO-MARQUÉS, Laura, GRACIA LAVEDAN, Esther, ARAGONÈS SANZ, Núria, OLMEDO REQUENA, Rocío, LLORCA DÍAZ, Javier, VIDÁN, Juana, AMIANO, Pilar, NOS, Pilar, FERNÁNDEZ TARDÓN, Guillermo, RADA, Ricardo, CHIRLAQUE, María dolores, GUINÓ, Elisabet, DÁVILA BATISTA, Verónica, CASTAÑO-VINYALS, Gemma, PÉREZ GÓMEZ, Beatriz, MIRÓN POZO, Benito, DIERSSEN SOTOS, Trinidad, ETXEBERRIA, Jaione, MOLINUEVO, Amaia, ÁLVAREZ-CUENLLAS, Begoña, KOGEVINAS, Manolis, POLLÁN, Marina, MORENO AGUADO, Víctor. Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study. _Scientific Reports_. 2018. Vol. 8, núm. 1, pàgs. 2040. [consulta: 1 de febrer de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/121875]

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