Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

ruperez2017_2629.pdf (165.18 KB)

Document type

Article

Version

Accepted version

Publication date

2017-07-17

All rights reserved

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/115802

Maternal HIV infection is an important health determinant in non-HIV-infected infants

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

http://dx.doi.org/10.1097/QAD.0000000000001499

Abstract

OBJECTIVE: To assess morbidity and mortality in HIV-exposed uninfected (HEU) children to help guiding appropriate clinical care and effective preventive interventions. DESIGN: This is a longitudinal study comparing two cohorts of children; one born to HIV-infected women and the other born to HIV-uninfected women. METHODS: We have analyzed prospectively obtained information on nutritional status, morbidity and mortality from 966 HEU and 909 HIV-unexposed infants followed up until their first 18 months of life at a referral health facility in southern Mozambique. Determinants for adverse health outcomes in HEU children were also assessed using multivariate logistic regression. RESULTS: Increased incidence of hospital admissions (P = 0.0015), shorter survival in the first 18 months of life (P = 0.0510) and moderate and severe malnutrition (P = 0.0006 and 0.0014, respectively) were observed among HEU children compared with HIV-unexposed children. Incidence of outpatient attendance in HEU children was associated with being men, older age and the mother being on antiretroviral treatment. Among HEU children, those who were never breastfed, or who were weaned or were partially breastfed, had an increased incidence of hospital admissions compared with children who were exclusively breastfed. CONCLUSION: Maternal HIV infection has important health consequences in non-HIV-infected children. As the prevalence of HIV-infected pregnant women is maintained and the proportion of HIV-infected children declines because of the scale-up of antiretroviral treatment during pregnancy and breastfeeding, more focus should be given to the health needs of HEU children to ensure that the post-2015 sustainable development goals are met.

Subject

VIH (Virus), Neonatologia, Mortalitat infantil, Morbiditat

Subject (English)

HIV (Viruses), Neonatology, Infant mortality, Morbidity

Citation

Collections

Articles publicats en revistes (ISGlobal)

Citation

RUPÉREZ, María, et al. Maternal HIV infection is an important health determinant in
                non-HIV-infected infants. AIDS. 2017. Vol. 31, num. 11, pags. 1545-1553. ISSN 0269-9370. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/115802

Export metadata

JSON - METS

Share record