Dynamic biomarkers in hormone receptor-positive/HER2-negative breast cancer trials: a new hope for precision oncology

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dc.contributor.authorGrazia, Giuseppe Di
dc.contributor.authorSchettini, Francesco
dc.contributor.authorSánchez Bayona, Rodrigo
dc.contributor.authorCasals Pascual, Climent
dc.contributor.authorPascual, Tomás
dc.contributor.authorGenerali, Daniele
dc.contributor.authorGennari, Alessandra
dc.contributor.authorVigneri, Paolo
dc.contributor.authorHarbeck, Nadia
dc.contributor.authorCortés, Javier
dc.contributor.authorPrat Aparicio, Aleix
dc.date.accessioned2026-04-29T17:29:52Z
dc.date.available2026-04-29T17:29:52Z
dc.date.issued2026-01-28
dc.date.updated2026-04-29T17:29:53Z
dc.description.abstractHormone receptor-positive/HER2-negative breast cancer evolves in response to therapy, demanding smarter, adaptive biomarker-based treatment strategies. We review emerging dynamic biomarkers to guide therapeutic decision-making, spanning tissue and liquid biopsies, metabolic imaging, and microbiome profiling, that capture tumor or host-related changes over time. By contrasting Academic and Industry approaches, we advocate for a cultural shift in clinical trial design and implementation, aiming to move from reactive to proactive Oncology.
dc.format.extent9 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec769784
dc.identifier.issn2374-4677
dc.identifier.pmid41605941
dc.identifier.urihttps://hdl.handle.net/2445/229253
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/s41523-026-00904-5
dc.relation.ispartofnpj Breast Cancer, 2026, vol. 12, 34
dc.relation.urihttps://doi.org/10.1038/s41523-026-00904-5
dc.rightscc-by (c) Giuseppe Di Grazia et al., 2026
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Fonaments Clínics)
dc.subject.classificationAssaigs clínics de medicaments
dc.subject.classificationCàncer de mama
dc.subject.classificationHormonoteràpia
dc.subject.otherDrug testing
dc.subject.otherBreast cancer
dc.subject.otherHormone therapy
dc.titleDynamic biomarkers in hormone receptor-positive/HER2-negative breast cancer trials: a new hope for precision oncology
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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