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1996

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/18658

Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis

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http://dx.doi.org/10.1136/gut.38.6.899

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BACKGROUND: 5-Lipoxygenase products play a part in inflammatory response. AIMS: The effect of intracolonic administration of zileuton (a 5-lipoxygenase inhibitor) on colonic damage and eicosanoid local release was assessed in a rat model of colitis. METHODS: Ninety rats with trinitrobenzenesulphonic acid induced colitis were randomised to receive placebo, 5-aminosalicylic acid (50 mg/kg), or zileuton (50 mg/kg) intracolonically for four weeks. Local eicosanoid release was monitored by intracolonic dialysis throughout the study. The colon was removed for macroscopic and histological assessment at weeks 1, 2, and 4 after colitis induction in 10 rats of each group. RESULTS: Zileuton significantly reduced macroscopic damage score after four weeks of treatment in comparison with the other two groups (p = 0.034). In addition, zileuton administration significantly increased the intracolonic release of both thromboxane B2 at week 1 (p = 0.05) and prostaglandin E2 at weeks 2 and 4 (p < 0.05). Zileuton and 5-aminosalicylic acid decreased leukotriene B4 release by 90% at day 3. CONCLUSIONS: Intracolonic zileuton, compared with 5-aminosalicylic acid and placebo, seems to improve the course of the disease in a model of chronic colitis. This effect may be related to an increased and maintained production of prostaglandin E2 together with inhibition of leukotriene B4 synthesis.

Matèries

Colitis, Còlon, Antienzims, Terapèutica

Matèries (anglès)

Colitis, Colon, Enzyme inhibitors, Therapeutics

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Col·leccions

Articles publicats en revistes (Medicina)

Citació

BERTRÁN, X., MAÑÉ ALMERO, Josep, FERNÁNDEZ BAÑARES, Fernando, CASTELLÀ, E., BARTOLÍ, R., OJANGUREN SABÁN, Isabel, ESTEVE I COMAS, Maria, GASSULL, Miquel àngel. Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis. _Gut_. 1996. Vol. 38, núm. 6, pàgs. 899-904. [consulta: 21 de gener de 2026]. ISSN: 0017-5749. [Disponible a: https://hdl.handle.net/2445/18658]

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