Transforming growth factor -α expression in rat experimental hepatocarcinogenesis

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dc.contributor.authorPérez Tomás, Ricardo E.
dc.contributor.authorMayol, X.
dc.contributor.authorCulleré i Luengo, F. Xavier
dc.contributor.authorDíaz Ruiz, Carmen
dc.contributor.authorDomingo i Feliudabaló, Jordi
dc.date.accessioned2017-01-20T08:24:54Z
dc.date.available2017-01-20T08:24:54Z
dc.date.issued1992-07
dc.date.updated2017-01-20T08:24:54Z
dc.description.abstractGrowth factors in general and transforming growth factor-alpha in particular have been related to cell proliferation and cell differentiation. This study was designed to clarify the distribution pattem of TGF-alpha in chemically-induced hepatocarcinogenesis. Sprague- Dawley rats were subjected to different non-intensive or intensive carcinogenic treatments using diethylnitrosamine (DEN) as carcinogen and ethinyl estradiol (EE) as promoter. The livers were fixed in 2% paraformaldehyde, dehydrated in a series of ethanol solutions, embedded in paraffin and sectioned. In the preneoplastic lesions no TGF-alpha immunoreactive cells were identified, but in some hepatic tumours cell immunostained with TGF-alpha antibody were observed. These results suggest that the cells capable of expressing TGF-a constitutively may be involved in neoplastic development in vivo.
dc.format.extent6 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec073060
dc.identifier.issn0213-3911
dc.identifier.urihttps://hdl.handle.net/2445/105882
dc.language.isoeng
dc.publisherUniversidad de Murcia
dc.relation.isformatofReproducció del document publicat a: https://digitum.um.es/xmlui/handle/10201/18324
dc.relation.ispartofHistology and Histopathology, 1992, vol. 7, num. 3, p. 457-462
dc.rightscc-by-nc-nd (c) Universidad de Murcia, 1992
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es
dc.sourceArticles publicats en revistes (Patologia i Terapèutica Experimental)
dc.subject.classificationTumors
dc.subject.classificationCèl·lules hepàtiques
dc.subject.classificationRates (Animals de laboratori)
dc.subject.classificationFactors de creixement
dc.subject.classificationCàncer de fetge
dc.subject.classificationHistopatologia veterinària
dc.subject.otherTumors
dc.subject.otherLiver cells
dc.subject.otherRats as laboratory animals
dc.subject.otherGrowth factors
dc.subject.otherLiver cancer
dc.subject.otherVeterinary histopathology
dc.titleTransforming growth factor -α expression in rat experimental hepatocarcinogenesis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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