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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/105882
Transforming growth factor -α expression in rat experimental hepatocarcinogenesis
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Growth factors in general and transforming growth factor-alpha in particular have been related to cell proliferation and cell differentiation. This study was designed to clarify the distribution pattem of TGF-alpha in chemically-induced hepatocarcinogenesis. Sprague- Dawley rats were subjected to different non-intensive or intensive carcinogenic treatments using diethylnitrosamine (DEN) as carcinogen and ethinyl estradiol (EE) as promoter. The livers were fixed in 2% paraformaldehyde, dehydrated in a series of ethanol solutions, embedded in paraffin and sectioned. In the preneoplastic lesions no TGF-alpha immunoreactive cells were identified, but in some hepatic tumours cell immunostained with TGF-alpha antibody were observed. These results suggest that the cells capable of expressing TGF-a constitutively may be involved in neoplastic development in vivo.
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PÉREZ TOMÁS, Ricardo E., et al. Transforming growth factor -α expression in rat experimental hepatocarcinogenesis. Histology and Histopathology. 1992. Vol. 7, num. 3, pags. 457-462. ISSN 0213-3911. [consulted: 5 of October of 2026]. Available at: https://hdl.handle.net/2445/105882