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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/215881
Impact of excision type, cone volume, and dimensions on persistence/recurrence of cervical intraepithelial neoplasia 2-3
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The objective of this study was to evaluate the relationship between the excision type and the persistence/recurrence of CIN2-3. A total of 227 women with CIN2-3 who were treated with LLETZ were evaluated. The types of excision according to the IFCPC 2011, volume, cone dimensions, margins of resection, post-cone high-risk human papillomavirus (HR-HPV) status, and viral load were studied. The time to recurrence was assessed using Kaplan-Meier curves. Persistent/recurrent CIN2-3 was found in 12 cases (5.2%). Type 1 excision was performed in 107 patients, with 7 recurrences (6.5%); type 2 excision in 74 patients, with 4 recurrences (5.4%); and type 3 excision in 46 patients, with 1 recurrence (2.1%). The percentage of clear margins in type 1 excisions was 44.9%, that in type 2 excisions was 59.5%, and that in type 3 excisions was 69.6% (p = 0.008). Type 1 excision was associated with 28.5% post-LLETZ HR-HPV positivity, that in type 2 reached 20.6%, and that in type 3 reached 11.4%; this difference was non-significant (p = 0.24). (4) Conclusions: Type 3 excision was associated with a larger proportion of clear margins and lower post-cone HR-HPV positivity, with a lower incidence of the persistence/recurrence of CIN2-3.
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MEDINA BUENO, Gonzalo Arturo, et al. Impact of excision type, cone volume, and dimensions on persistence/recurrence of cervical intraepithelial neoplasia 2-3. Life. 2024. Vol. 14, num. 8. ISSN 2075-1729. [consulted: 10 of June of 2026]. Available at: https://hdl.handle.net/2445/215881