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bm-32-1-010706.pdf (261.8 KB)

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2022-02-15

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cc by (c) Castro Castro, María José et al, 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183998

Dynamic profiles and predictive values of some biochemical and haematological quantities in COVID-19 inpatients

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https://doi.org/10.11613/BM.2022.010706

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Introduction: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in some hospitalized patients has shown some important alterations in laboratory tests. The aim of this study was to establish the most relevant quantities associated with the worst prognosis related to COVID-19. Materials and methods: This was a descriptive, longitudinal, observational and retrospective study, in a cohort of 845 adult inpatients from Bellvitge University Hospital (L'Hospitalet de Llobregat, Barcelona, Spain). A multivariate regression analysis was carried out in demographic, clinical and laboratory data, comparing survivors (SURV) and non-survivors (no-SURV). A receiver operating characteristic analysis was also carried out to establish the cut-off point for poor prognostic with better specificity and sensibility. Dynamic changes in clinical laboratory measurements were tracked from day 1 to day 28 after the onset of symptoms. Results: During their hospital stay, 18% of the patients died. Age, kidney disease, creatinine (CREA), lactate-dehydrogenase (LD), C-reactive-protein (CRP) and lymphocyte (LYM) concentration showed the strongest independent associations with the risk of death in the multivariate regression analysis. Established cut-off values for poor prognosis for CREA, LD, CRP and LYM concentrations were 75.0 mu mol/L, 320 U/L, 80.9 mg/L and 0.69 x10(9)/L. Dynamic profile of laboratory findings, were in agreement with the consequences of organ damage and tissue destruction. Conclusions: Age, kidney disease, CREA, LD, CRP and LYM concentrations in COVID-19 patients from the southern region of Catalonia provide important information for their prognosis. Measurement of LD has demonstrated to be very good indicator of poor prognosis at initial evaluation because of its stability over time.

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COVID-19, Pronòstic mèdic

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COVID-19, Prognosis

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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CASTRO CASTRO, María josé, GARCÍA TEJADA, Laura, ARBIOL ROCA, Ariadna, SÁNCHEZ NAVARRO, Lourdes, RAPÚN MAS, Loreto, CACHÓN SUÁREZ, Isabel, ÁLVAREZ ÁLVAREZ, Marta, DOT BACH, Dolors, GÜELL MIRÓ, Roser, CORTÉS BOSCH DE BASEA, Anna, DASTIS ARIAS, Macarena, SANCHO CERRO, Ana, DÍAZ TROYANO, Noelia, ESCARTÍN DIEZ, Teresa, MUÑOZ PROVENCIO, Diego, NAVARRO BADAL, Rosa. Dynamic profiles and predictive values of some biochemical and haematological quantities in COVID-19 inpatients. _Biochemia Medica_. 2022. Vol.  vol 32, núm. num 1, pàgs. 74-84. [consulta: 21 de gener de 2026]. ISSN: 1846-7482. [Disponible a: https://hdl.handle.net/2445/183998]

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