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88651.pdf (900.02 KB)

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Article

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Versió publicada

Data de publicació

1992

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/18676

Portal hypertension in acute liver failure

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ISSN de la revista

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Recurs relacionat

http://dx.doi.org/10.1136/gut.33.7.965

Resum

Twenty five patients with acute liver failure were measured for hepatic venous pressure gradient as an index of portal pressure during the course of a transjugular liver biopsy. Hepatic venous pressure gradient ranged from 4 to 24.5 mm Hg with a mean of 12.8 (5.3) mm Hg (normal values less than 5 mm Hg). All patients but one had increased portal pressure gradient. Portal hypertension correlated with the degree of architectural distortion of the liver, as suggested by a direct correlation between hepatic venous pressure gradient and the area of reticulin collapse, evaluated by means of a morphometric analysis on Sirius red stained liver slides (r = 0.43, p less than 0.05). Hepatic venous pressure gradient was significantly higher in patients with ascites (15.1 (5) mm Hg, n = 15) or renal failure (14.4 (5.3) mm Hg, n = 16) than in those without (9.3 (3.4) mm Hg and 10.1 (4) mm Hg, respectively; p less than 0.05). Portal hypertension was associated with systemic vasodilation and a hyperkinetic circulatory state, with decreased arterial pressure, and peripheral resistance and increased cardiac output.

Matèries

Hipertensió portal, Malalties del fetge, Fetge

Matèries (anglès)

Portal hypertension, Liver diseases, Liver

Citació

Col·leccions

Articles publicats en revistes (Medicina)

Citació

NAVASA, Miquel, et al. Portal hypertension in acute liver failure. Gut. 1992. Vol. 33, num. 965-968. ISSN 0017-5749. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/18676

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