Miniatura

Fitxers

710309.pdf (1.7 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2019-10-31

Llicència de publicació

cc-by (c) Ceausu, Andrea et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/177008

IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1038/s41598-019-52025-8

Resum

A relationship between polymorphisms in genes encoding interleukin 7 (IL-7) and its cellular receptor (IL-7R) and antiretroviral therapy (ART)-associated immune recovery in HIV subjects has been previously reported. However, details of this relationship remain unclear, and the association of these polymorphisms with circulating IL-7/IL-7R levels is scarce. Here, we explored whether IL-7/IL-7R axis was associated with quantitative CD4+ T-cell recovery in HIV-infected subjects. IL-7/IL-7R polymorphisms were assessed by genotyping, and multiple inheritance models were used to estimate both, their association with low pre-ART CD4+ T-cell counts and incomplete immune recovery status after 48 weeks of suppressive ART. Integrated data from genetic variants association and soluble plasma IL-7/IL-7R quantification suggest that IL-7/IL-7R genotype expression could alter the homeostatic balance between soluble and membrane-bound receptors. The haplotype analyses indicates that allele combinations impacts pre-ART circulating CD4+ T-cell counts, immune recovery status and the absolute increment of CD4+ T-cell counts. The knowledge about how IL-7/IL-7R axis is related to quantitative CD4+ T-cell recovery and immune recovery status after initiating ART could be useful regarding T-cell reservoirs investigations in HIV subjects.

Matèries

Polimorfisme genètic, Interleucines

Matèries (anglès)

Genetic polymorphisms, Interleukins

Citació

Col·leccions

Articles publicats en revistes (Medicina)

Citació

CEAUSU, Andrea, RODRÍGUEZ GALLEGO, Esther, PERAIR, Joaquim, LÓPEZ DUPLA, Miguel, DOMINGO, Pere (domingo pedrol), VILADÉS, Consuelo, VIDAL GONZALEZ, Judit, PERAIRE, María, PERPIÑÁN, Carles, PACHECO, Yolanda maría, VELOSO, Sergi, ALBA, Verónica, VARGAS, Montserrat, CASTELLANO, Alfonso j., RUÍZ MATEOS, Ezequiel, MALLOLAS MASFERRER, Josep, VIDAL MARSAL, Francisco, RULL, Anna. IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status. _Scientific Reports_. 2019. Vol. 9, núm. 1, pàgs. 15722. [consulta: 15 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/177008]

Exportar metadades

JSON - METS

Compartir registre