Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimer's disease

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dc.contributor.authorDel Amo Albiol, Laura
dc.contributor.authorCano Fernández, Amanda
dc.contributor.authorEttcheto Arriola, Miren
dc.contributor.authorSouto, Eliana B.
dc.contributor.authorEspina García, Marta
dc.contributor.authorCamins Espuny, Antoni
dc.contributor.authorGarcía, Maria Luisa
dc.contributor.authorSánchez-López, E. (Elena)
dc.date.accessioned2021-05-20T10:42:23Z
dc.date.available2021-05-20T10:42:23Z
dc.date.issued2021-05-10
dc.date.updated2021-05-20T10:42:23Z
dc.description.abstractAlzheimer's disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. Nanosized particles have been proposed as suitable drug delivery systems to overcome BBB with the purpose of increasing bioavailability of drugs in the brain. Biodegradable poly (lactic-co-glycolic acid) nanoparticles (PLGA-NPs) have been particularly regarded as promising drug delivery systems as they can be surface-tailored with functionalized molecules for site-specific targeting. In this review, a thorough discussion about the most recent functionalization strategies based on PLGA-NPs for AD and their mechanisms of action is provided, together with a description of AD pathogenesis and the role of the BBB in brain targeting. Keywords: functionalized PLGA nanoparticles; brain delivery; blood-brain barrier; Alzheimer's disease
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec712200
dc.identifier.issn2076-3417
dc.identifier.urihttps://hdl.handle.net/2445/177480
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/app11094305
dc.relation.ispartofApplied Sciences, 2021
dc.relation.urihttps://doi.org/10.3390/app11094305
dc.rightscc-by (c) Del Amo Albiol, Laura et al., 2021
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
dc.subject.classificationMalaltia d'Alzheimer
dc.subject.classificationNanopartícules
dc.subject.classificationFarmacologia
dc.subject.otherAlzheimer's disease
dc.subject.otherNanoparticles
dc.subject.otherPharmacology
dc.titleSurface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimer's disease
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)