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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/178991
Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents
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Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we describe a new AMP family, namely the supercationic peptide dendrimers (SCPDs). Although all members of the series exert some antibacterial activity, we propose that special attention should be given to (KLK)2KLLKLL-NH2 (G1KLK-L2KL2), which shows selectivity for Gram-negative bacteria and virtually no cytotoxicity in HepG2 and HEK293. These results reinforce the validity of the SCPD family as a valuable class of AMP and support G1KLK-L2KL2 as a strong lead candidate for the future development of an antibacterial agent against Gram-negative bacteria.
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RAMCHURAN, Estelle J., et al. Super-Cationic Peptide Dendrimers¿Synthesis and Evaluation as Antimicrobial Agents. Antibiotics. 2021. Vol. 10, num. 6, pags. 695. ISSN 2079-6382. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/178991