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2014-11-01

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/106264

Disruption of brain white matter microstructure in females with anorexia nervosa

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https://doi.org/10.1503/jpn.130135

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Background: The etiology of anorexia nervosa is still unknown. Multiple and distributed brain regions have been implicated in its pathophysiology, implying a dysfunction of connected neural circuits. Despite these findings, the role of white matter in anorexia nervosa has been rarely assessed. In this study, we used diffusion tensor imaging (DTI) to characterize alterations of white matter microstructure in a clinically homogeneous sample of patients with anorexia nervosa. Methods: Women with anorexia nervosa (restricting subtype) and healthy controls underwent brain DTI. We used tract-based spatial statistics to compare fractional anisotropy (FA) and mean diffusivity (MD) maps between the groups. Furthermore, axial (AD) and radial diffusivity (RD) measures were extracted from regions showing group differences in either FA or MD. Results: We enrolled 19 women with anorexia nervosa and 19 healthy controls in our study. Patients with anorexia nervosa showed significant FA decreases in the parietal part of the left superior longitudinal fasciculus (SLF; pFWE < 0.05), with increased MD and RD but no differences in AD. Patients with anorexia nervosa also showed significantly increased MD in the fornix (pFWE < 0.05), accompanied by decreased FA and increased RD and AD. Limitations: Limitations include our modest sample size and cross-sectional design. Conclusion: Our findings support the presence of white matter pathology in patients with anorexia nervosa. Alterations in the SLF and fornix might be relevant to key symptoms of anorexia nervosa, such as body image distortion or impairments in body-energy-balance and reward processes. The differences found in both areas replicate those found in previous DTI studies and support a role for white matter pathology of specific neural circuits in individuals with anorexia nervosa.

Matèries

Anorèxia nerviosa, Dones, Circuit neuronal, Cervell

Matèries (anglès)

Anorexia nervosa, Women, Neural circuitry, Brain

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

VIA VIRGILI, Esther, ZALESKY, Andrew, SÁNCHEZ ZAPLANA, Isabel, FORCANO, Laura, HARRISON, Ben j., PUJOL NUEZ, Jesús, FERNÁNDEZ ARANDA, Fernando, MENCHÓN MAGRIÑÁ, José manuel, SORIANO MAS, Carles, CARDONER, N. (narcís), FORNITO, Alex. Disruption of brain white matter microstructure in females with anorexia nervosa. _Journal of Psychiatry & Neuroscience_. 2014. Vol. 39, núm. 6, pàgs. 367-375. [consulta: 20 de gener de 2026]. ISSN: 1180-4882. [Disponible a: https://hdl.handle.net/2445/106264]

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