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2025-11-26

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cc-by (c) Anguluri, K. et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/224709

Rose Bengal-incorporated supramolecular gels as a topical platform for localized antimicrobial photodynamic therapy<br />

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https://doi.org/10.3390/ijms262311455

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Efficient and localized singlet oxygen (SO) generation is essential for improving antimicrobial photodynamic therapy (aPDT). In this study, a bis-imidazolium-based amphiphilic gelator is used, which self-assembles into a supramolecular gel in a water–ethanol medium and incorporates Rose Bengal (RB) as a photosensitizer. The gel network provides a confined environment that promotes SO formation under light irradiation. RB@Gel was characterized with respect to its morphology, degradation behavior, and swelling properties. Biopharmaceutical assessment included in vitro release, ex vivo permeation studies and Hen’s Egg Test–Chorioallantoic Membrane (HET-CAM) assay. Rheological measurements confirmed a viscoelastic profile, indicating structural stability and suitability for localized therapeutic applications. SO production within the gel was quantified using tetrasodium 9,10-anthracenediyl-bis(methylene)dimalonate (NaABMA), showing higher efficiency than that of RB in solution. The RB@Gel exhibited significant aPDT against E. coli in a direct-surface contact assay. Overall, the RB@Gel provides a stable, suitable platform capable of efficient SO generation and potent antibacterial activity, highlighting its promise for localized aPDT applications.

Matèries

Compostos heterocíclics, Química farmacèutica, Gels (Farmàcia)

Matèries (anglès)

Heterocyclic compounds, Pharmaceutical chemistry, Gels (Pharmacy)

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Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

Citació

ANGULURI, Kavya, et al. Rose Bengal-incorporated supramolecular gels as a topical platform for localized antimicrobial photodynamic therapy
. International Journal of Molecular Sciences. 2025. Vol. 26, num. 23, pags. 11455. ISSN 1661-6596. [consulted: 24 of May of 2026]. Available at: https://hdl.handle.net/2445/224709

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