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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/224709
Rose Bengal-incorporated supramolecular gels as a topical platform for localized antimicrobial photodynamic therapy<br />
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Efficient and localized singlet oxygen (SO) generation is essential for improving antimicrobial photodynamic therapy (aPDT). In this study, a bis-imidazolium-based amphiphilic gelator is used, which self-assembles into a supramolecular gel in a water–ethanol medium and incorporates Rose Bengal (RB) as a photosensitizer. The gel network provides a confined environment that promotes SO formation under light irradiation. RB@Gel was characterized with respect to its morphology, degradation behavior, and swelling properties. Biopharmaceutical assessment included in vitro release, ex vivo permeation studies and Hen’s Egg Test–Chorioallantoic Membrane (HET-CAM) assay. Rheological measurements confirmed a viscoelastic profile, indicating structural stability and suitability for localized therapeutic applications. SO production within the gel was quantified using tetrasodium 9,10-anthracenediyl-bis(methylene)dimalonate (NaABMA), showing higher efficiency than that of RB in solution. The RB@Gel exhibited significant aPDT against E. coli in a direct-surface contact assay. Overall, the RB@Gel provides a stable, suitable platform capable of efficient SO generation and potent antibacterial activity, highlighting its promise for localized aPDT applications.
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ANGULURI, Kavya, BAGHERPOUR, Saman, CALPENA CAMPMANY, Ana cristina, HALBAUT, Lyda, ESPARGARÓ COLOMÉ, Alba, SABATÉ LAGUNAS, Raimon, PÉREZ-GARCÍA, Lluïsa. Rose Bengal-incorporated supramolecular gels as a topical platform for localized antimicrobial photodynamic therapy<br />. _International Journal of Molecular Sciences_. 2025. Vol. 26, núm. 23, pàgs. 11455. [consulta: 29 de gener de 2026]. ISSN: 1661-6596. [Disponible a: https://hdl.handle.net/2445/224709]