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s41598-021-88734-2.pdf (1.93 MB)

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2021-04-28

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cc by (c) Cano Jiménez et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/178514

Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis

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https://doi.org/10.1038/s41598-021-88734-2

Resum

Rheumatoid arthritis (RA) is a systemic autoimmune disease whose main extra-articular organ affected is the lung, sometimes in the form of diffuse interstitial lung disease (ILD) and conditions the prognosis. A multicenter, observational, descriptive and cross-sectional study of consecutive patients diagnosed with RA-ILD. Demographic, analytical, respiratory functional and evolution characteristics were analyzed to evaluate the predictors of progression and mortality. 106 patients were included. The multivariate analysis showed that the diagnostic delay was an independent predictor of mortality (HR 1.11, CI 1.01-1.23, p = 0.035). Also, age (HR 1.33, 95% CI 1.09-1.62, p = 0.0045), DLCO (%) (HR 0.85, 95% CI 0.73-0.98, p = 0.0246), and final SatO2 (%) in the 6MWT (HR 0.62, 95% CI 0.39-0.99, p = 0.0465) were independent predictor variables of mortality, as well as GAP index (HR 4.65, 95% CI 1.59-13.54, p = 0.0051) and CPI index (HR 1.12, 95% CI 1.03-1.22, p = 0.0092). The withdrawal of MTX or LFN after ILD diagnosis was associated with disease progression in the COX analysis (HR 2.18, 95% CI 1.14-4.18, p = 0.019). This is the first study that highlights the diagnostic delay in RA-ILD is associated with an increased mortality just like happens in IPF.

Matèries

Malalties del pulmó, Artritis reumatoide, Mortalitat

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Pulmonary diseases, Rheumatoid arthritis, Mortality

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

CANO JIMÉNEZ, Esteban alberto, VÁZQUEZ RODRÍGUEZ, Tomás, MARTÍN ROBLES, Irene, CASTILLO VILLEGAS, Diego, JUAN GARCÍA, Javier, BOLLO DE MIGUEL, Elena, ROBLES-PÉREZ, Alejandro, FERRER GALVÁN, Marta, MOURONTE ROIBAS, Cecilia, HERRERA LARA, Susana, BERMUDO, Guadalupe, GARCÍA MOYANO, Marta, RODRÍGUEZ PORTAL, Jose antonio, SELLARÉS TORRES, Jacobo, NARVÁEZ, Javier, MOLINA MOLINA, María. Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis. _Scientific Reports_. 2021. Vol. 11. [consulta: 25 de febrer de 2026]. [Disponible a: https://hdl.handle.net/2445/178514]

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