Effect of a Probiotic Combination on Clinical and Microbiological Oral Parameters in Head and Neck Cancer Patients: A Randomised Clinical Trial

Abstract

Patients with head and neck cancer undergoing radiotherapy frequently experience xerostomia and disturbances in the oral bacterial balance, which can significantly impair their quality of life. This study investigated whether a 30-day daily intake of a probiotic combination could enhance salivary function and reduce disease-associated oral bacteria. Participants were randomly assigned to receive either probiotics or a placebo. By the end of the intervention, those in the probiotic group showed notable improvements in stimulated salivary flow and a reduction in overall bacterial counts, particularly Fusobacterium nucleatum. These results suggest that probiotics may represent a safe and effective approach to prevent or mitigate radiotherapy-induced oral complications. This study highlights the potential role of probiotics as a simple and supportive measure to improve oral health and overall well-being during cancer treatment recovery.