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549534.pdf (220 KB)

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Data de publicació

2007

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/18684

Aggregation of liposomes induced by calcium: A structural and kinetic study

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Recurs relacionat

http://dx.doi.org/10.1103/PhysRevE.75.021912

Resum

In this work, the calcium-induced aggregation of phosphatidylserine liposomes is probed by means of the analysis of the kinetics of such process as well as the aggregate morphology. This novel characterization of liposome aggregation involves the use of static and dynamic light-scattering techniques to obtain kinetic exponents and fractal dimensions. For salt concentrations larger than 5 mM, a diffusion-limited aggregation regime is observed and the Brownian kernel properly describes the time evolution of the diffusion coefficient. For slow kinetics, a slightly modified multiple contact kernel is required. In any case, a time evolution model based on the numerical resolution of Smoluchowski's equation is proposed in order to establish a theoretical description for the aggregating system. Such a model provides an alternative procedure to determine the dimerization constant, which might supply valuable information about interaction mechanisms between phospholipid vesicles.

Matèries

Física mèdica, Liposomes, Calci

Matèries (anglès)

Medical physics, Liposomes, Calcium

Citació

Col·leccions

Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

Citació

ROLDÁN-VARGAS, Sándalo, et al. Aggregation of liposomes induced by calcium: A structural and kinetic study. Physical Review e. 2007. Vol. 75, num. 2, pags. 021912-1-021912-10. ISSN 1063-651X. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/18684

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