Document type
ArticleVersion
Accepted versionPublication date
All rights reserved
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/128330
In vitro activity of 12 antimicrobial peptides against Mycobacterium tuberculosis and Mycobacterium avium clinical isolates
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Tuberculosis (TB) remains a major threat to human health
worldwide. The increasing incidence of non-tuberculous
mycobacterial infections and particularly those produced by
Mycobacterium avium has emphasized the need to develop new
drugs. Additionally, high levels of natural drug resistance in
non-tuberculous mycobacteria (NTM) and the emergence of
multidrug-resistant (MDR) TB is of great concern. Antimicrobial
peptides (AMPs) are antibiotics with broad-spectrum
antimicrobial activity. The objective was to assess the activity
of AMPs against Mycobacterium tuberculosis and M. avium clinical
isolates. MICs were determined using microtitre plates and the
resazurin assay. Mastoparan and melittin showed the greatest
activity against M. tuberculosis, while indolicidin had the
lowest MIC against M. avium. In conclusion, AMPs could be
alternatives for the treatment of mycobacterial infections.
Further investigation of AMPs' activity in combination and
associated with conventional antibiotics and their loading into
drug-delivery systems could lead to their use in clinical
practice.
Subject (English)
Citation
Citation
PORTELL BUJ, Elena, et al. In vitro activity of 12 antimicrobial peptides against Mycobacterium tuberculosis and Mycobacterium avium clinical isolates. Journal of Medical Microbiology. 2019. Vol. 68, num. 2. ISSN 0022-2615. [consulted: 17 of June of 2026]. Available at: https://hdl.handle.net/2445/128330