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In vitro activity of 12 antimicrobial peptides against Mycobacterium tuberculosis and Mycobacterium avium clinical isolates
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Tuberculosis (TB) remains a major threat to human health
worldwide. The increasing incidence of non-tuberculous
mycobacterial infections and particularly those produced by
Mycobacterium avium has emphasized the need to develop new
drugs. Additionally, high levels of natural drug resistance in
non-tuberculous mycobacteria (NTM) and the emergence of
multidrug-resistant (MDR) TB is of great concern. Antimicrobial
peptides (AMPs) are antibiotics with broad-spectrum
antimicrobial activity. The objective was to assess the activity
of AMPs against Mycobacterium tuberculosis and M. avium clinical
isolates. MICs were determined using microtitre plates and the
resazurin assay. Mastoparan and melittin showed the greatest
activity against M. tuberculosis, while indolicidin had the
lowest MIC against M. avium. In conclusion, AMPs could be
alternatives for the treatment of mycobacterial infections.
Further investigation of AMPs' activity in combination and
associated with conventional antibiotics and their loading into
drug-delivery systems could lead to their use in clinical
practice.
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PORTELL BUJ, Elena, VERGARA GÓMEZ, Andrea, ALEJO-CANCHO, Izaskun, LÓPEZ GAVÍN, Alexandre, MONTÉ, Maria rosa, SAN NICOLÁS, Lorena, GONZÁLEZ MARTÍN, Julián, TUDÓ I VILANOVA, Griselda. In vitro activity of 12 antimicrobial peptides against Mycobacterium tuberculosis and Mycobacterium avium clinical isolates. _Journal of Medical Microbiology_. 2019. Vol. 68, núm. 2. [consulta: 25 de febrer de 2026]. ISSN: 0022-2615. [Disponible a: https://hdl.handle.net/2445/128330]