Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress

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dc.contributor.authorRezvani, Maryam
dc.contributor.authorManca, Maria Letizia
dc.contributor.authorCaddeo, Carla
dc.contributor.authorEscribano Ferrer, Elvira
dc.contributor.authorCarbone, Claudia
dc.contributor.authorPeris, José Esteban
dc.contributor.authorUsach, Iris
dc.contributor.authorDiez-Sales, Octavio
dc.contributor.authorFadda, Anna Maria
dc.contributor.authorManconi, Maria
dc.date.accessioned2021-02-11T10:30:10Z
dc.date.available2021-02-11T10:30:10Z
dc.date.issued2019
dc.date.updated2021-02-11T10:30:10Z
dc.description.abstractThe present study aimed at developing a new vesicular formulation capable of promoting the protective effect of ascorbic acid and tocopherol against intestinal oxidative stress damage, and their efficacy in intestinal wound healing upon oral administration. A pH-dependent copolymer (Eudragit® L100), a water-soluble prebiotic fibre (Nutriose® FM06), a phospholipid mixture (Lipoid S75), and two natural antioxidants (ascorbic acid and tocopherol) were combined to fabricate eudragit-nutriosomes by a simple, solvent-free procedure. The vesicles were spherical and oligolamellar, with some multicompartment structures in Eudragit-nutriosomes, small in size (~100 nm), with highly negative zeta potential. The effect of Eudragit® and Nutriose® on the stability on storage and in simulated gastrointestinal fluids were confirmed by the Turbiscan® technology and in vitro studies, respectively. Eudragit-nutriosomes exhibited a protective effect against H2O2-induced oxidative stress, and a proliferative effect in Caco-2 cells, as they provided the closure of the scratched area after 96 h of incubation. Keywords: Eudragit, Nutriose, phospholipid vesicles, antioxidant, intestinal wound healing
dc.format.extent10 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec683802
dc.identifier.issn1999-4923
dc.identifier.pmid30621127
dc.identifier.urihttps://hdl.handle.net/2445/173852
dc.language.isoeng
dc.publisherMDPI
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/pharmaceutics11010013
dc.relation.ispartofPharmaceutics, 2019, vol. 11, p. 13-22
dc.relation.urihttps://doi.org/10.3390/pharmaceutics11010013
dc.rightscc-by (c) Rezvani, Maryam et al., 2019
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
dc.subject.classificationVitamina C
dc.subject.classificationVitamina E
dc.subject.classificationCicatrització
dc.subject.classificationIntestins
dc.subject.classificationNeuroimmunologia
dc.subject.otherVitamin C
dc.subject.otherVitamin E
dc.subject.otherWound healing
dc.subject.otherIntestines
dc.subject.otherNeuroimmunology
dc.titleCo-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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