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2019-07-04

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cc-by (c) Pedrola, Marina et al., 2019
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/165079

Multicomponent Reactions upon the Known Drug Trimethoprim as a Source of Novel Antimicrobial Agents

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https://doi.org/10.3389/fchem.2019.00475

Abstract

Novel antibiotic compounds have been prepared through a selective multicomponent reaction upon the known drug Trimethoprim. The Groebke-Blackburn-Bienaymé reaction involving this α-aminoazine, with a range of aldehydes and isocyanides afforded the desired adducts in one-step. The analogs display meaningful structural features of the initial drug together with relevant modifications at several points, keeping antibiotic potency and showing satisfactory antimicrobial profile (good activity levels and reduced growth rates), especially against methicillin-resistant Staphylococcus aureus. The new products may open new possibilities to fight bacterial infections.

Subject

Antibiòtics, Medicaments, Bacteris, Isonitrils

Subject (English)

Antibiotics, Drugs, Bacteria, Isocyanides

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Citation

PEDROLA, Marina, et al. Multicomponent Reactions upon the Known Drug Trimethoprim as a Source of Novel Antimicrobial Agents. Frontiers in Chemistry. 2019. Vol. 7, num. 475. ISSN 2296-2646. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/165079

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