Multicomponent Reactions upon the Known Drug Trimethoprim as a Source of Novel Antimicrobial Agents

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dc.contributor.authorPedrola, Marina
dc.contributor.authorJorba, Marta
dc.contributor.authorJardas, Eda
dc.contributor.authorJardi, Ferran
dc.contributor.authorGhashghaei, Ouldouz
dc.contributor.authorViñas, Miquel
dc.contributor.authorLavilla Grífols, Rodolfo
dc.date.accessioned2020-06-10T15:05:35Z
dc.date.available2020-06-10T15:05:35Z
dc.date.issued2019-07-04
dc.date.updated2020-06-10T15:05:35Z
dc.description.abstractNovel antibiotic compounds have been prepared through a selective multicomponent reaction upon the known drug Trimethoprim. The Groebke-Blackburn-Bienaymé reaction involving this α-aminoazine, with a range of aldehydes and isocyanides afforded the desired adducts in one-step. The analogs display meaningful structural features of the initial drug together with relevant modifications at several points, keeping antibiotic potency and showing satisfactory antimicrobial profile (good activity levels and reduced growth rates), especially against methicillin-resistant Staphylococcus aureus. The new products may open new possibilities to fight bacterial infections.
dc.format.extent9 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec691038
dc.identifier.issn2296-2646
dc.identifier.pmid31334221
dc.identifier.urihttps://hdl.handle.net/2445/165079
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3389/fchem.2019.00475
dc.relation.ispartofFrontiers in Chemistry, 2019, vol. 7, p. 475
dc.relation.urihttps://doi.org/10.3389/fchem.2019.00475
dc.rightscc-by (c) Pedrola, Marina et al., 2019
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationAntibiòtics
dc.subject.classificationMedicaments
dc.subject.classificationBacteris
dc.subject.classificationIsonitrils
dc.subject.otherAntibiotics
dc.subject.otherDrugs
dc.subject.otherBacteria
dc.subject.otherIsocyanides
dc.titleMulticomponent Reactions upon the Known Drug Trimethoprim as a Source of Novel Antimicrobial Agents
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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