Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió acceptadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/146044
Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
BACKGROUND & AIMS: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. METHODS: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-α and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. RESULTS: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. CONCLUSIONS: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity.
Matèries
Matèries (anglès)
Citació
Citació
CANTERO, Irene, ABETE, Itziar, BABIO, Nancy, ARÓS, Fernando, CORELLA PIQUER, Dolores, ESTRUCH RIBA, Ramon, FITÓ COLOMER, Montserrat, HÉBERT, James r., MARTÍNEZ-GONZÁLEZ, Miguel ángel, PINTÓ SALA, Xavier, PORTILLO, María puy, RUIZ CANELA, Miguel, SHIVAPPA, Nitin, WÄRNBERG, Julia, GÓMEZ GRACIA, Enrique, TUR, Josep antoni, SALAS SALVADÓ, Jordi, ZULET, M. angeles, MARTÍNEZ, J. alfredo. Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial. _Clinical Nutrition_. 2018. Vol. 37, núm. 5, pàgs. 1736-1743. [consulta: 20 de gener de 2026]. ISSN: 0261-5614. [Disponible a: https://hdl.handle.net/2445/146044]