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s41598-021-91275-3.pdf (962.49 KB)

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2021-06-03

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cc by (c) Papantoniou, Kyriaki et al., 2021
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/179173

Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study

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https://doi.org/10.1038/s41598-021-91275-3

Abstract

Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case-control study (2008-2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR≥9 hours: 1.59; 95%CI 1.30-1.94) and gastric cancer (OR≥9 hours: 1.95; 1.37-2.76); short sleep was associated with increased odds of gastric cancer (OR≤5 hours: 1.32; 0.93-1.88). Frequent and long daytime naps increased the odds of colorectal (OR6-7 naps/week, ≥30 min: 1.32; 1.14-1.54) and gastric cancer (OR6-7 naps/week, ≥30 min: 1.56; 1.21-2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer.

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Càncer gastrointestinal, Factors de risc en les malalties, Son, Cáncer gastrointestinal

Subject (English)

Colorectal cancer, Risk factors in diseases, Sleep, Gastrointestinal cancer

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (ISGlobal)

Citation

PAPANTONIOU, Kyriaki, et al. Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study. Scientific Reports. 2021. Vol. 11, num. 11822. ISSN 2045-2322. [consulted: 10 of August of 2026]. Available at: https://hdl.handle.net/2445/179173

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