Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

710313.pdf (490.64 KB)

Document type

Article

Version

Published version

Publication date

2019-12-04

Publication license

cc-by (c) Perelló, R. et al., 2019
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/177068

Cytomegalovirus infection in HIV-infected patients in the era of combination antiretroviral therapy

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1186/s12879-019-4643-6

Abstract

Background: Cytomegalovirus infection dramatically decreased with the introduction of antiretroviral therapy. Whether incidence, clinical characteristics and prognosis of cytomegalovirus in HIV infected patients, has changed over time is. scarcely known. Methods: Retrospective single-center study. Patients included in this study were all HIV infected patients that went to our center for any disease, and were diagnosed with cytomegalovirus, during the period 2004-2015. epidemiological, clinical and laboratory patients variables were collected in a clinical database. Clinical characteristics, incidence of cytomegalovirus and predictors of mortality during the study were assessed. Results were considered statistically significant when p < 0.05. All statistical analyses were calculated by SPSS version 20.0 (Chicago, IL,USA). Results: Fifty-six cases of cytomegalovirus infection, in HIV infected patients were identified during the study period (incidence rate-1.7 cases per 1000 persons/year). The most frequent presentation was systemic illness in 43% of cases. Of note,no patients presented with ophthalmic manifestations. The 30-days mortality was 18%. Predictors of mortality were, in the univariate analysis, admission to the intensive care unit OR 32.4 (3.65-287.06) p = 0.0001, and mechanic ventilation 84 OR (8.27-853.12) p = 0.0001, and ART OR 4.1 (0.97-17.31) p = 0.044. These variables were assessed by multivariate analysis, and only mechanical ventilation was statistically significant (p < 0.05) CONCLUSION: Incidence of cytomegalovirus infection was higher than described in the antiretroviral therapy era. Clinical presentation has changed. Mechanic ventilation predicted mortality.

Subject

Fòbies en els infants, Suïcidi

Subject (English)

Phobias in children, Suicide

Citation

Collections

Articles publicats en revistes (Medicina)

Citation

PERELLÓ, R., et al. Cytomegalovirus infection in HIV-infected patients in the era of combination antiretroviral therapy. BMC Infectious Diseases. 2019. Vol. 19, num. 1, pags. 1030. ISSN 1471-2334. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/177068

Export metadata

JSON - METS

Share record