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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/177068
Cytomegalovirus infection in HIV-infected patients in the era of combination antiretroviral therapy
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Background: Cytomegalovirus infection dramatically decreased with the introduction of antiretroviral therapy. Whether incidence, clinical characteristics and prognosis of cytomegalovirus in HIV infected patients, has changed over time is. scarcely known. Methods: Retrospective single-center study. Patients included in this study were all HIV infected patients that went to our center for any disease, and were diagnosed with cytomegalovirus, during the period 2004-2015. epidemiological, clinical and laboratory patients variables were collected in a clinical database. Clinical characteristics, incidence of cytomegalovirus and predictors of mortality during the study were assessed. Results were considered statistically significant when p < 0.05. All statistical analyses were calculated by SPSS version 20.0 (Chicago, IL,USA). Results: Fifty-six cases of cytomegalovirus infection, in HIV infected patients were identified during the study period (incidence rate-1.7 cases per 1000 persons/year). The most frequent presentation was systemic illness in 43% of cases. Of note,no patients presented with ophthalmic manifestations. The 30-days mortality was 18%. Predictors of mortality were, in the univariate analysis, admission to the intensive care unit OR 32.4 (3.65-287.06) p = 0.0001, and mechanic ventilation 84 OR (8.27-853.12) p = 0.0001, and ART OR 4.1 (0.97-17.31) p = 0.044. These variables were assessed by multivariate analysis, and only mechanical ventilation was statistically significant (p < 0.05) CONCLUSION: Incidence of cytomegalovirus infection was higher than described in the antiretroviral therapy era. Clinical presentation has changed. Mechanic ventilation predicted mortality.
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PERELLÓ, R., VERGARA, A., JIMÉNEZ, S., MONTERO, M., SAUBI, N., MORENO, A., ETO, Y., INCIARTE PORTILLO, Alexy, MALLOLAS MASFERRER, Josep, MARTÍNEZ, E., MARCOS, Ma. angeles. Cytomegalovirus infection in HIV-infected patients in the era of combination antiretroviral therapy. _BMC Infectious Diseases_. 2019. Vol. 19, núm. 1, pàgs. 1030. [consulta: 24 de gener de 2026]. ISSN: 1471-2334. [Disponible a: https://hdl.handle.net/2445/177068]