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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/126169
Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis
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Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in JAK3 gene have been associated with CV events in incident dialysis patients. Therefore, the aim of this study was to assess the potential role of JAK3 polymorphisms in the development of CV disease in patients with RA. 2136 Spanish RA patients were genotyped for the rs3212780 and rs3212752 JAK3 gene polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 539 of these patients by carotid ultrasonography (US). No statistically significant differences were found when each polymorphism was assessed according to carotid intima-media thickness values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV events after adjusting for potential confounders. In conclusion, our results do not confirm association between JAK3 polymorphisms and CV disease in RA.
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GARCÍA BERMÚDEZ, Mercedes, LÓPEZ MEJÍAS, Raquel, GENRE, Fernanda, CASTAÑEDA, Santos, CORRALES, Alfonso, LLORCA DÍAZ, Javier, GONZÁLEZ JUANATEY, Carlos, UBILLA, Begoña, MIRANDA-FILLOY, José a., PINA, Trinitario, GÓMEZ VAQUERO, Carmen, RODRÍGUEZ-RODRÍGUEZ, Luis, FERNÁNDEZ GUTIÉRREZ, Benjamín, BALSA, Alejandro, PASCUAL-SALCEDO, Dora, LÓPEZ LONGO, Francisco j., CARREIRA, Patricia, BLANCO, Ricardo, MARTÍN, Javier, GONZÁLEZ-GAY, Miguel a.. Lack Of Association Between Jak3 Gene Polymorphisms And Cardiovascular Disease In Spanish Patients With Rheumatoid Arthritis. _BioMed Research International_. 2015. [consulta: 20 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/126169]