Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

663764.pdf (2.4 MB)

Document type

Article

Version

Accepted version

Publication date

2016-05-31

All rights reserved

Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/101694

Functionalized surfaces with tailored wettability determine Influenza A infectivity

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

http://dx.doi.org/10.1021/acsami.6b02779

Abstract

Surfaces contaminated with pathogenic microorganisms contribute to their transmission and spreading. The development of 'active surfaces' that can reduce or eliminate this contamination necessitates a detailed understanding of the molecular mechanisms of interactions between the surfaces and the microorganisms. Few studies have shown that, among the different surface characteristics, the wetting properties play an important role in reducing virus infectivity. Here, we systematically tailored the wetting characteristics of flat and nanostructured glass surfaces by functionalizing them with alkyl- and fluoro-silanes. We studied the effects of these functionalized surfaces on the infectivity of Influenza A viruses using a number of experimental and computational methods including real-time fluorescence microscopy and molecular dynamics simulations. Overall, we show that surfaces that are simultaneously hydrophobic and oleophilic are more efficient in deactivating enveloped viruses. Our results suggest that the deactivation mechanism likely involves disruption of the viral membrane upon its contact with the alkyl chains. Moreover, enhancing these specific wetting characteristics by surface nanostructuring led to an increased deactivation of viruses. These combined features make these substrates highly promising for applications in hospitals and similar infrastructures where antiviral surfaces can be crucial.

Subject

Grip aviària, Superfícies hidrofòbiques, Microscòpia de fluorescència, Materials nanoestructurats, Dinàmica molecular

Subject (English)

Avian influenza, Hydrophobic surfaces, Fluorescence microscopy, Nanostructured materials, Molecular dynamics

Citation

Collections

Articles publicats en revistes (Ciència dels Materials i Química Física)

Citation

MANNELLI, Ilaria, et al. Functionalized surfaces with tailored wettability determine Influenza A infectivity. ACS Applied Materials & Interfaces. 2016. Vol. 8, num. 24, pags. 15058-15066. ISSN 1944-8244. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/101694

Export metadata

JSON - METS

Share record