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2022-12-09

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cc-by (c) Diaz-Mercedes, S. et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/209370

Cytology Smears: An Enhanced Alternative Method for Colorectal Cancer pN Stage-A Multicentre Study

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https://doi.org/10.3390/cancers14246072

Resum

Stage II colorectal cancer (CRC) recurrence remains a clinical problem. Some of these patients are true stage III CRC with a pN0 pathology stage. This large prospective multicentre cohort study aimed at evaluating the diagnostic ability of lymph node (LN) cytology smears to perform the pN stage and compare it with the conventional haematoxylin and eosin (H&E) pathology pN stage. Additionally, we used the One-Step Nucleic Acid Amplification (OSNA), a high-sensitive molecular method of LN staging. A total of 3936 fresh LNs from 217 CRC surgical specimens were examined by three methods, H&E, LN cytology smears, and OSNA. H&E detected 29% of patients with positive LNs, cytology smears 35%, and OSNA 33.2% (p < 0.0001). H&E and cytology concordantly classified 92.2% of tumours, and 88.5% between OSNA and H&E. Cytology had 96.8% sensitivity and 90.3% specificity to discriminate positive/negative patients compared to H&E (p = 0.004), and 87.3% sensitivity and 89% specificity when compared to OSNA (p = 0.56). Patients with positive LNs detected by any of the three methods had significantly worse disease-free and overall survival. We conclude that pN stage accuracy for detecting positive LNs is superior with LN cytological smears than with conventional H&E, which would enable a better pN stage and management of early-stage CRC patients.

Matèries

Nodes limfàtics, Citologia, Càncer colorectal

Matèries (anglès)

Lymph nodes, Cytology, Colorectal cancer

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Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

DIAZ MERCEDES, Sherley, ARCHILLA SANZ, Iván, LAHOZ, Sara, RODRIGO CALVO, María teresa, LÓPEZ PRADES, Sandra, TARRAGONA, Jordi, LANDOLFI, Stefania, CONCHA, Ángel, MACHADO, Isidro, MAUREL SANTASUSANA, Joan, CHIC RUCHÉ, Núria, CASTELLS, Antoni, BALAGUER PRUNÉS, Francesc, CAMPS, Jordi, CUATRECASAS FREIXAS, Miriam. Cytology Smears: An Enhanced Alternative Method for Colorectal Cancer pN Stage-A Multicentre Study. _Cancers_. 2022. Vol. 14, núm. 24. [consulta: 21 de gener de 2026]. ISSN: 2072-6694. [Disponible a: https://hdl.handle.net/2445/209370]

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