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long_term_liver_stiffness_dynamics_after_sustained.3.pdf (289.37 KB)

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2025-09-23

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cc-by-nc-nd (c) Martín Carmona, Jésica et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/228761

Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis

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https://doi.org/10.1097/QAD.0000000000004357

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Objective: This study analyses liver stiffness (LS) dynamics in people with HIV (PWH) and advanced liver fibrosis who achieved sustained virological response (SVR) and assess factors associated with LS normalization or progression, after long-term follow-up.Design:Prospective multicenter cohort study. Methods: This study included individuals with HIV/HCV co-infection from the Spanish GEHEP-011 cohort, fulfilling: pretreatment LS >= 9.5 kPa; sustained virological response (SVR) with direct-acting antiviral regimen; available measurement of LS at SVR. Factors associated with LS normalization (achieving <= 7.2 kPa in two consecutive measurement) and progression (increase of >20% LS at the last measurement available) were analyzed. Results: A total of 678 patients were included. The median follow-up was 40 (17-71) months. The repeated measures ANOVA revealed a significant main effect of time on LS. Overall, 221 (32.6%) achieved normalization. Lower probability of normalization was associated with advanced liver disease [baseline LS: sHR = 0.26 (95% CI, 0.19-0.37), P < 0.001; liver decompensation before SVR: sHR = 0.22 (0.05-0.97), P < 0.001; baseline MELD score: sHR = 0.81 (0.69-0.94), P = 0.006]. LS progression occurred in 50 (7.4%). Progression was associated with higher baseline LS [sHR = 1.04 (1.01-1.07), P = 0.007], controlled attenuation parameter (CAP) [CAP >= 280 dB/m: sHR = 2.94 (1.16-7.44)] and older age [sHR 1.06 (1.00-1.13), per year, P = 0.04]. Conclusions: In PWH, LS significantly decreases after HCV cure in the long-term, achieving values of <= 7.2 kPa. In a substantial proportion of patients, LS remain stable or even increases. Older age and concomitant steatotic liver disease are associated with LS progression.

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Infeccions per VIH, Hepatitis C, Malalties del fetge

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HIV infections, Hepatitis C, Liver diseases

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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MARTÍN CARMONA, Jésica, CORONA MATA, Diana, TÉLLEZ, Francisco, NAVARRETE LORITE, Miguel nicolás, BARROSO, Isabel, CARLOS ALADOS, Juan, PALACIOS MUÑOZ, Rosario, SANTOS, Ignacio de los, VERA MÉNDEZ, Francisco jesús, IMAZ, Arkaitz, RAFFO MÁRQUEZ, Miguel, MORANO VÁZQUEZ, Aitana carla, JOSÉ GALINDO, María, BELINCHÓN, Olga, SERRANO FUENTES, Miriam, LÓPEZ ZÚÑIGA, Miguel ángel, GALERA PEÑARANDA, Carlos, REUS BAÑULS, Sergio javier, PINEDA, Juan a., MACÍAS, Juan, CORMA GÓMEZ, Anaïs, Gehep-011 Study Group. Long-term liver stiffness dynamics after sustained virological response in patients with HIV/HCV co-infection and advanced fibrosis. _AIDS_. 2025. Vol. 40, núm. 2, pàgs. 151-159. [consulta: 3 de maig de 2026]. ISSN: 0269-9370. [Disponible a: https://hdl.handle.net/2445/228761]

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